Tolerability

» Calcium products are generally considered to be safe and well tolerated

» The data available for the tolerability of Calcia Calcium tablets show that the product is well tolerated

» In a study by Lebas et al, Calcia Calcium 500 mg was given twice daily for up to 6 months to 1340 patients with a median age of 64 years¹

» Adverse events were infrequent; this table shows the most commonly reported adverse events after 3 and 6 months of treatment¹

» The majority of adverse events occurred in patients who were also receiving concomitant medication unrelated to calcium supplementation¹

¹ Lebas JF et al. Acceptabilité et tolérance du carbonate de calcium Théramex (Orocal 500 mg) lors d’un traitement au long cours. Le Concours Medical 1992; 4: 1-4.

» Calcia treatment causes few side effects

» In a study by Thomas and Meunier, patients (n=190) were randomised to receive either two chewable tablets, each containing 500 mg calcium and 400 IU vitamin D₃ (Calcia), or two sachets, each containing 500 mg calcium in the form of calcium gluconolactate and carbonate, plus 2 drops vitamin D₂ (400 IU per drop), twice daily for at least 10 weeks¹

» The adverse-event symptoms were monitored before and after treatment and are detailed in this table¹

» Both treatments were well tolerated, although Calcia tablets caused fewer adverse events, especially abdominal bloating¹

¹ Thomas JL, Meunier PJ. Evaluation of acceptability, tolerance and observance of a new calcium-vitamin D combination. Rhumatologie 1996; 48: 37-42.